Blar i forfatter "Østman, Arne"

Viser treff 1-2 av 2

    • Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Vik, Jørg; de Petris, Luigi; Dønnem, Tom; Strell, Carina; Østman, Arne; Busund, Lill-Tove; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)
      Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) ...

    • Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Østman, Arne; Strell, Carina; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)
      Objectives: <br> Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize with immune-checkpoint inhibitors. While the roles of CAFs in cancer development are well described, their immune-regulatory properties remain incompletely understood. This study investigates correlations between CAF and immune-markers in tumor stroma from nonsmall cell lung cancer (NSCLC) ...